The Rundown AI is reporting that Biohub, a nonprofit backed by Mark Zuckerberg and Priscilla Chan’s CZI, has released new Evolutionary Scale Models, including ESMFold2 and ESM Atlas. It said these models create an open system to map, predict, and design proteins, showing results against cancer and immune disease targets. The ESMFold2 model, trained on 2.8 billion sequences, predicts protein structure and designs proteins, claiming state-of-the-art performance and outperforming AlphaFold. Biohub said it has already designed binders against five cancer and immune targets with high hit rates. The ESM Atlas provides a map of 6.8 billion protein sequences and 1.1 billion predicted structures, revealing novel evolutionary connections. The Rundown AI noted that Biohub's $500 million Virtual Biology Initiative and open-source tools aim to accelerate protein discovery for researchers.
The Rundown AI is also reporting that OpenAI Foundation, the nonprofit arm owning 26% of OpenAI’s for-profit business, has committed an initial $250 million. It said these funds will support grants, partnerships, and direct work to help workers, communities, and economies navigate AI-driven disruption. The Foundation plans to track AI's economic impact, support worker retraining and job transitions, and explore long-term economic security measures like tax shifts from labor to capital, sovereign wealth funds, and durable stakes in AI-generated value. The Rundown AI noted that the first initiatives are expected later this year, with many arguing for quicker action due to current layoffs and worker anxiety.
Additionally, The Rundown AI is reporting that Trajectory, a new startup founded by former DeepMind and Apple researchers, has launched with $15 million in seed funding. It said the company aims to build a platform for continual learning, enabling AI to improve from real-world experience rather than remaining static after initial training. Trajectory captures user corrections, retries, and edits from product data to continuously post-train models, which it claims outperform frontier AI on specific tasks. The startup is currently updating models weekly and is working towards hourly or per-interaction updates.
In other AI developments, OpenAI will remove GPT-5.2 and GPT-5.3-Codex from Codex on June 2, making GPT-5.5 the default for free users. Google debuted Coral Board, a low-power development platform for on-device AI applications. Anthropic rolled out reliability upgrades for Claude Code. Robinhood launched Agentic Trading and an Agentic Credit Card, allowing AI agents to execute stock trades and manage spending. YouTube announced automatic AI-generated content detection with prominent labels for synthetic videos and broader access to deepfake-detection tools. Cognition announced a $1 billion funding round at a $26 billion valuation, reporting over 10x growth since January, driven by its Devin AI software engineer.