SUMMARY: New research strategies are needed to find out how information flows through the brain's neural networks, according to neuroscientists at Rice University and Baylor College of Medicine. In a new article in Neuron, the researchers suggest using complex experiments to test the most important properties of these networks.
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Simple tasks don't test brain's true complexity
Rice, Baylor College of Medicine duo details agenda for modeling problem-solving networks
HOUSTON – (June 7, 2017) – The human brain naturally makes its best guess when making a decision, and studying those guesses can be very revealing about the brain’s inner workings. But neuroscientists at Rice University and Baylor College of Medicine said a full understanding of the complexity of the human brain will require new research strategies that better simulate real-world conditions.
Xaq Pitkow and Dora Angelaki, both faculty members in Baylor's Department of Neuroscience and Rice's Department of Electrical and Computer Engineering, said the brain's ability to perform "approximate probabilistic inference" cannot be truly studied with simple tasks that are "ill-suited to expose the inferential computations that make the brain special."
A new article by the researchers suggests the brain uses nonlinear message-passing between connected, redundant populations of neurons that draw upon a probabilistic model of the world. That model, coarsely passed down via evolution and refined through learning, simplifies decision-making based on general concepts and its particular biases.
The article, which lays out a broad research agenda for neuroscience, is featured this month in a special edition of Neuron, a journal published by Cell Press. The edition presents ideas that first appeared as part of a workshop at the University of Copenhagen last September titled "How Does the Brain Work?"
"Evolution has given us what we call a good model bias," Pitkow said. "It's been known for a couple of decades that very simple neural networks can compute any function, but those universal networks can be enormous, requiring extraordinary time and resources.
"In contrast, if you have the right kind of model -- not a completely general model that could learn anything, but a more limited model that can learn specific things, especially the kind of things that often happen in the real world -- then you have a model that's biased. In this sense, bias can be a positive trait. We use it to be sensitive to the right things in the world that we inhabit. Of course, the flip side is that when our brain’s bias is not matched to reality, it can lead to severe problems."
The researchers said simple tests of brain processes, like those in which subjects choose between two options, provide only simple results. "Before we had access to large amounts of data, neuroscience made huge strides from using simple tasks, and they'll remain very useful," Pitkow said. "But for computations that we think are most important about the brain, there are things you just can't reveal with some of those tasks." Pitkow and Angelaki wrote that tasks should incorporate more diversity -- like nuisance variables and uncertainty -- to better simulate real-world conditions that the brain evolved to handle.
They suggested that the brain infers solutions based on statistical crosstalk between redundant population codes. Population codes are responses by collections of neurons that are sensitive to certain inputs, like the shape or movement of an object. Pitkow and Angelaki think that to better understand the brain, it can be more useful to describe what these populations compute, rather than precisely how each individual neuron computes it. Pitkow said this means thinking "at the representational level" rather than the "mechanistic level," as described by the influential vision scientist David Marr.
The research has implications for artificial intelligence, another interest of both researchers.
"A lot of artificial intelligence has done impressive work lately, but it still fails in some spectacular ways," Pitkow said. "They can play the ancient game of Go and beat the best human player in the world, as done recently by DeepMind’s AlphaGo about a decade before anybody expected. But AlphaGo doesn’t know how to pick up the Go pieces. Even the best algorithms are extremely specialized. Their ability to generalize is often still pretty poor. Our brains have a much better model of the world; We can learn more from less data. Neuroscience theories suggest ways to translate experiments into smarter algorithms that could lead to a greater understanding of general intelligence."
Pitkow is an assistant professor in the Department of Neuroscience and co-director of the Center for Neuroscience and Artificial Intelligence at Baylor and is an assistant professor of electrical and computer engineering at Rice. Angelaki is the Wilhelmina Robertson Professor of Neurosurgery at Baylor and an adjunct professor of electrical and computer engineering and of psychology at Rice.
The research was supported by the McNair Foundation, the National Science Foundation, Britton Sanderford, the Intelligence Advance Research Projects Activity via the Department of Interior/Interior Business Center, the Simons Collaboration on the Global Brain and the National Institutes of Health.
Read the abstract at http://www.cell.com/neuron/abstract/S0896-6273(17)30466-X
This news release can be found online at http://news.rice.edu/2017/06/07/simple-tasks-dont-test-brains-true-complexity/
Follow Rice News and Media Relations via Twitter @RiceUNews
Xaq Lab: http://xaqlab.com
Angelaki Lab: https://www.bcm.edu/research/labs/dora-angelaki
Neuroscience-Inspired Networks for Artificial Intelligence (NINNI): http://www.ninai.org
Rice Department of Electrical and Computer Engineering: https://www.ece.rice.edu
Baylor Department of Neuroscience: https://www.bcm.edu/departments/neuroscience
Image for download:
Rice University and Baylor College of Medicine researchers are taking a deep look at the models by which the brain infers correct decisions. The graphic outlines, from left, interrelated variables in a simple statistical model, a neural network model with populations of neurons that capture the same structure, and a variant of the neural network collapsed into a more realistic overlapping configuration. All three images represent populations of neurons that hold specific models of the world. The researchers are working to untangle these networks to determine how the brain infers solutions to problems without being overwhelmed by data. (Credit: Xaq Pitkow/Dora Angelaki)
Xaq Pitkow. (Credit: Agapito/Baylor College of Medicine)
Dora Angelaki. (Credit: Baylor College of Medicine)
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